The Origin of Quantal Size Variation: Vesicular Glutamate Concentration Plays a Significant Role
نویسندگان
چکیده
منابع مشابه
The origin of quantal size variation: vesicular glutamate concentration plays a significant role.
Fusion of a single vesicle induces a quantal response, which is critical in determining synaptic strength. Quantal size varies at most synapses. Its underlying mechanisms are not well understood. Here, we examined five sources of variation: vesicular glutamate concentration ([Glu]v), vesicle volume, ultrafast fusion pore closure, the postsynaptic receptor, and the location between release and t...
متن کاملPresynaptic regulation of quantal size by the vesicular glutamate transporter VGLUT1.
A fundamental question in synaptic physiology is whether the unitary strength of a synapse can be regulated by presynaptic characteristics and, if so, what those characteristics might be. Here, we characterize a newly proposed mechanism for altering the strength of glutamatergic synapses based on the recently identified vesicular glutamate transporter VGLUT1. We provide direct evidence that fil...
متن کاملPresynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport
It is known that the response to release of neurotransmitter from a single synaptic vesicle (quantal size) can vary as a result of postsynaptic changes in receptors1, but considerably less is known about the presynaptic regulation of quantal size through changes in vesicle filling with transmitter. Glutamate receptors are not saturated at the calyx of Held2,3 and synapses in the hippocampus and...
متن کاملAn essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size.
Quantal neurotransmitter release at excitatory synapses depends on glutamate import into synaptic vesicles by vesicular glutamate transporters (VGLUTs). Of the three known transporters, VGLUT1 and VGLUT2 are expressed prominently in the adult brain, but during the first two weeks of postnatal development, VGLUT2 expression predominates. Targeted deletion of VGLUT1 in mice causes lethality in th...
متن کاملVesicular glutamate transporter VGLUT2 expression levels control quantal size and neuropathic pain.
Uptake of L-glutamate into synaptic vesicles is mediated by vesicular glutamate transporters (VGLUTs). Three transporters (VGLUT1-VGLUT3) are expressed in the mammalian CNS, with partial overlapping expression patterns, and VGLUT2 is the most abundantly expressed paralog in the thalamus, midbrain, and brainstem. Previous studies have shown that VGLUT1 is necessary for glutamatergic transmission...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2007
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.4415-06.2007